England U18 international Maro Itoje will also make his debut for Saracens in the back row.
Jamie George starts at hooker while Carlos Nieto, Nils Mordt, James Short, Duncan Taylor and Joe Maddock are also in the line-up while Adam Powell also returns from injury. Another player returning from injury is flanker Justin Melck to be named on the bench for his first appearance of the season while he is joined among the replacements by John Smit and Alistair Hargreaves.
The Saracens bench also includes Bedford Blues prop Darren Fearn and scrum half Ali Price. Wing Jack Wilson, on loan from Bay of Plenty, is also a replacement.
Saracens line-up vs Cardiff Blues
15 Alex Goode
14 Joe Maddock
13 Duncan Taylor
12 Adam Powell
11 James Short
10 Nils Mordt ©
9 Ben Spencer
1 Nick Auterac
2 Jamie George
3 Carlos Nieto
4 Eoin Sheriff
5 Mouritz Botha
6 Maro Itoje
7 Nick Fenton-Wells
8 Tom Jubb
16 John Smit
17 Darren Fearn
18 Petrus du Plessis
19 Alistair Hargreaves
20 Justin Melck
21 Ali Price
22 Sam Stanley
23 Jack Wilson
