In the forwards, Dave Ward starts at hooker, with Charlie Matthews and Sam Twomey completing the front five.
Luke Wallace, who has been shortlisted for this season's "LV= breakthrough player of the year award", captains the side and is joined in the back-row with Tom Guest and Joe Trayfoot.
Among the replacements, Harry Allen will look to make his first appearance for the club, while Ross Chisholm is named after recovering from an ankle injury sustained against Leicester Tigers in September.
Harlequins Team
15. Ollie Lindsay-Hague
14. Seb Stegmann
13. Matt Hopper
12. Tom Casson
11. Sam Smith
10. Ben Botica
9. Karl Dickson
1. Mark Lambert
2. Dave Ward
3. Will Collier
4. Sam Twomey
5. Charlie Matthews
6. Joe Trayfoot
7. Luke Wallace (C)
8. Tom Guest
16. Harry Allen
17. Darryl Marfo
18. Kyle Sinckler
19. Jack Clifford
20. Harry Sloan
21. Jordan Burns
22. Louis Grimoldby
23. Ross Chisholm