New signing Pat Phibbs will start at scrum half and Steven Shingler and Sailosi Tagicakibau will form the centre combination. Jonathan Joseph moves to the wing.
London Irish Director of Rugby Brian Smith said: "We've trained well this week and we're looking forward to the contest tomorrow.
Gloucester are a very good team and deserve to go into the match as favourites, however we are looking at the contest as an opportunity to claim a big scalp. There is some history between the two clubs in recent times and the boys are very aware of that."
London Irish team to face Gloucester:
15. Tom Homer; 14. Jonathan Joseph*; 13. Sailosi Tagicakibau*; 12. Steven Shingler; 11. Marland Yarde; 10. Ian Humphreys; 9. Patt Phibbs; 1. Alex Corbisiero*; 2. David Paice*; 3. Halani Aulika*; 4. George Skivington; 5. Bryn Evans* (Captain); 6. Matt Garvey; 7.Jebb Sinclair*; 8. Chris Hala'ufia*
Replacements: 16. Scott Lawson*; 17. Max Lahiff; 18.Leo Halavatau; 19. Kieran Low; 20. Jamie Gibson; 21. Guy Armitage; 22. Shane Geraghty*; 23. Jack Moates
*Denotes Internationals