Among the backs Ollie Lindsay-Hague comes in for Mike Brown at full back, while Jordan Tuner-Hall and George Lowe form the centre partnership in place of Tom Casson and Matt Hopper, with the latter named on the bench. The final change in the back line sees Sam Smith taking over from Ugo Monye on the left wing.
In the forwards Charlie Matthews comes in for Olly Kohn in the second row while Tom Guest starts at blindside flanker in place of Maurie Fa'asavalu.
Harlequins Team:
15. Ollie Lindsay-Hague
14. Tom Williams
13. George Lowe
12. Jordan Turner-Hall
11. Sam Smith
10. Nick Evans
9. Danny Care
1. Joe Marler
2. Joe Gray
3. James Johnston
4. Charlie Matthews
5. George Robson
6. Tom Guest
7. Chris Robshaw (C)
8. Nick Easter
Replacements:
16. Rob Buchanan
17. Mark Lambert
18. Will Collier
19. Sam Twomey
20. Luke Wallace
21. Karl Dickson
22. Ben Botica
23. Matt Hopper