Scrum half Jonny Arr will partner Andy Goode at half back, with former England international Paul Hodgson ruled out of the game with a jaw injury.
Centre Jon Clarke is also named in the back division with Josh Matavesi among the replacements.
Three changes in the pack see a return for hooker Aleki Lutui while Sam Betty plays in the back row alongside Matt Kvesic and Semisi Taulava. Ex-Ireland ace Neil Best is named on the bench and could make his 50th appearance for Warriors if he features.
Lock Dean Schofield will join James Percival, who retains the captaincy, in the second row.
Fit-again prop Matt Mullan is recalled to the bench alongside scrum half Ollie Frost.
Hill said: "There are a number of changes to the starting line-up as we look to keep the squad fresh after a run of bruising encounters.
"There were a number of battered and bruised bodies after the game at Sale and it is vital the team that starts is in the best physical shape for such a crucial game.
"Paul Hodgson misses out after picking up a jaw injury, but I know Jonny Arr will be keen to grasp this opportunity. We also call-up Aleki Lutui, Dean Schofield, Sam Betty, Jon Clarke and Josh Drauniniu and they will be determined to take advantage of this chance to shine.
"We have a real sense of pride when playing in front of our fans at Sixways, but this will undoubtedly be our toughest challenge yet," added Hill.
"If we want to keep our home record intact we have got to pull out all the stops and raise the bar once more against Leicester Tigers."
Tickets for the game remain available from the Warriors Box Office on 01905 454183.
Warriors vs. Leicester Tigers
15 Chris Pennell
14 Josh Drauniniu
13 Alex Grove
12 Jon Clarke
11 David Lemi
10 Andy Goode
9 Jonny Arr
1 Ceri Jones
2 Aleki Lutui
3 Euan Murray
4 James Percival (c)
5 Dean Schofield
6 Sam Betty
7 Matt Kvesic
8 Semisi Taulava
Replacements
16 Ed Shervington
17 Matt Mullan
18 John Andress
19 Chris Jones
20 Neil Best
21 Ollie Frost
22 Danny Gray
23 Josh Matavesi
