Danny Cipriani swaps with Mark Van Gisbergen as full back, whilst David Doherty comes back in at wing, where he started against Saracens in the opening game of the season. Injured Mark McMillan's place at scrum half is taken by Irish international, Eoin Reddan, who makes his first post World Cup club appearance of the season.
Director of Rugby, Ian McGeechan said, "I'm pleased to welcome both Dan Leo and Eoin Reddan back to the club following their return from World Cup duty, though injuries to Mark McMillan and Dominic Waldouck mean that we remain a very small squad."
"Similarly, the key to success for us remains managing our game over the full 80 minutes. That's the only reason we haven't got a win in the last two weeks, but that one reason has made a significant difference to our league position. We have to be very focussed on our performance in order to get the result we need on Friday."
London Wasps' team to face Sale Sharks on Friday 4th October, KO 7.45pm at Edgeley Park is:
15 Danny Cipriani
14 David Doherty
13 Fraser Waters
12 Riki Flutey
11 Tom Voyce
10 Dave Walder
9 Eoin Reddan
1 Tim Payne
2 Joe Ward
3 Pat Barnard
4 Richard Birkett
5 George Skivington
6 Dan Leo
7 James Haskell
8 John Hart (c)
16 Rob Webber
17 Michael Holford
18 Tom Palmer
19 Hugo Ellis
20 Simon Amor
21 Rob Hoadley
22 Mark Van Gisbergen